HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparative evaluation of bimatoprost monotherapy in primary chronic angle closure and primary open angle glaucoma eyes: a three-year study.

AbstractAIMS:
The aim of this study was to compare the long-term efficacy of bimatoprost 0.03% monotherapy in primary open angle glaucoma (POAG) versus primary chronic angle closure glaucoma (PCACG) eyes.
METHODS:
A total of 55 consecutive primary adult glaucoma patients on bimatoprost monotherapy were prospectively evaluated in this 3-year, open-labeled, uncontrolled study. The primary outcome was the evaluation of a difference in the response to therapy of POAG eyes, as compared to PCACG eyes over a follow-up of 3 years.
RESULTS:
In the POAG group, the mean intraocular pressure (IOP) at the 36-month followup was found to be increased by 2.10 (+/-3.90) mmHg (confidence interval [CI], 0.975-4.185), compared to the mean IOP at 1 month (P = 0.047). In the PCACG group, the mean IOP at the 36-month follow-up was increased by 3.66) (+/- 3.34) mmHg (CI, 6.241-1.092), compared to the mean IOP at 1 month (P = 0.011). This upward drift in IOP was higher in the PCACG group, compared to the POAG group, but this was not statistically significant (P = 0.54). Patients with POAG and PCACG showed a 50% and 40% chance of having an IOP of <18 mmHg with bimatoprost monotherapy (P = 0.23), respectively, at the 3-year follow-up.
CONCLUSIONS:
This study showed that bimatoprost 0.03% monotherapy significantly lowers IOP in both POAG and PCACG eyes over a period of 3 years, though its efficacy appeared to decrease over time, to a similar extent, in both groups.
AuthorsViney Gupta, Geetha Srinivasan, Ajay Sharma, Kulwant S Kapoor, Ramanjit Sihota
JournalJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 23 Issue 4 Pg. 351-8 (Aug 2007) ISSN: 1080-7683 [Print] United States
PMID17803433 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Amides
  • Antihypertensive Agents
  • Lipids
  • Cloprostenol
  • Bimatoprost
Topics
  • Administration, Topical
  • Aged
  • Amides (adverse effects, therapeutic use)
  • Antihypertensive Agents (adverse effects, therapeutic use)
  • Bimatoprost
  • Chronic Disease
  • Cloprostenol (adverse effects, analogs & derivatives, therapeutic use)
  • Female
  • Follow-Up Studies
  • Glaucoma, Angle-Closure (drug therapy)
  • Glaucoma, Open-Angle (drug therapy)
  • Humans
  • Intraocular Pressure (drug effects)
  • Lipids (adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Prospective Studies
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: