[Role of pentoxifylline retard dosage forms in the correction of hemodynamic disorders in retinal venous occlusion and diabetic retinopathy].

Abstract

The investigation was undertaken to study the effect of the pentoxifylline retard dosage form Vasonit on ocular hemodynamics in patients with retinal vein occlusions and non-proliferative diabetic retinopathy (DR). Forty-two patients aged 45 to 75 years, including 20 patients (20 eyes) with retinal vein occlusion in the presence of hypertensive disease and atherosclerosis (Group 1) and 22 patients (44 years) with non-proliferative DR (Group 2), were examined. All the patients received the pentoxifylline retard dosage form Vasonit, 600 mg twice a day, for 2 months. After a course of pentoxifylline therapy, the patients were observed to have improved visual functions, positive clinical changes in the fundus of the eye as a reduction in the frequency and extent of retinal hemorrhages, in the degree of manifestations of macular edema, in the number of retinal microaneurysms and ischemic areas. The results of color Doppler mapping of ocular and orbital vessels are indicative of improved hemodynamics as an increase in the values of blood flow velocity and normalization of blood flow resistance and pulsation indices in the arteries supplying blood to the retina and optic nerve.

• Authors: T N Kiseleva, G S Polunin, M V Budzinskaia, L V Korzenkova, D V Andzhelova, E A Kravchuk, Iu M Lagutina
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 2007 Jul-Aug Vol. 123 Issue 4 Pg. 9-14 ISSN: 0042-465X [Print] Russia (Federation)
• PMID: 17802753 (Publication Type: Journal Article)

Chemical References

• Platelet Aggregation Inhibitors
• Pentoxifylline

Topics

• Aged
• Blood Flow Velocity (drug effects, physiology)
• Diabetic Retinopathy (diagnosis, drug therapy, physiopathology)
• Dose-Response Relationship, Drug
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Humans
• Male
• Microcirculation (drug effects)
• Middle Aged
• Pentoxifylline (administration & dosage)
• Platelet Aggregation Inhibitors (administration & dosage)
• Retinal Vein Occlusion (diagnosis, drug therapy, physiopathology)
• Retinal Vessels (diagnostic imaging, physiopathology)
• Treatment Outcome
• Ultrasonography, Doppler, Color
• Visual Acuity