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Improved mobilization of peripheral blood CD34+ cells and dendritic cells by AMD3100 plus granulocyte-colony-stimulating factor in non-Hodgkin's lymphoma patients.

Abstract
AMD3100 is a drug capable of mobilizing peripheral blood stem cells (PBSCs) in donors and in cancer patients as a single agent or in combination with granulocyte-colony-stimulating factor (G-CSF). We initiated a phase II study of 11 refractory or relapsed non-Hodgkin's lymphoma (NHL) patients, receiving 16 microg/kg daily of G-CSF for 4 days followed by 240 microg/kg of AMD3100 given subcutaneously on a new schedule of 9-10 h before apheresis collection on day 5. Our aims were to assess the effect of AMD3100 on the mobilization of CD34+ cells, dendritic cells (DCs) and lymphoma cells. Administration of G-CSF and AMD3100 were continued daily until >or=2 x 10(6) CD34+ cells/kg were collected. Adequate collection of the target of CD34+ cells was achieved in all but 1 patient within 2 days, and 10/11 patients were transplanted within 2 months. All transplanted patients engrafted with a mean of 10 and 12 days for neutrophils and platelets, respectively. Addition of AMD3100 to G-CSF resulted with >2.5-fold increase in CD34+ cells/microl (p = 0.0001) and in a >2-fold increase in pDC1 and pDC2 cells/microl (p = 0.003). Adverse events related to AMD3100 were minimal. AMD3100 was generally safe and improved PBSC and DC cell mobilization with no apparent contamination of lymphoma cells.
AuthorsYair Gazitt, Cesar O Freytes, Cagla Akay, Karin Badel, Gary Calandra
JournalStem cells and development (Stem Cells Dev) Vol. 16 Issue 4 Pg. 657-66 (Aug 2007) ISSN: 1547-3287 [Print] United States
PMID17784839 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD
  • Antigens, CD34
  • Benzylamines
  • Cyclams
  • Heterocyclic Compounds
  • Receptors, CXCR4
  • Granulocyte Colony-Stimulating Factor
  • plerixafor
Topics
  • Adolescent
  • Adult
  • Aged
  • Antigens, CD (blood)
  • Antigens, CD34 (blood)
  • Benzylamines
  • Cyclams
  • Dendritic Cells (drug effects, physiology)
  • Granulocyte Colony-Stimulating Factor (pharmacology)
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells (drug effects, physiology)
  • Heterocyclic Compounds (pharmacology)
  • Humans
  • Lymphoma, Non-Hodgkin (blood, pathology, therapy)
  • Middle Aged
  • Neutrophils (transplantation)
  • Patient Selection
  • Receptors, CXCR4 (antagonists & inhibitors)
  • Recurrence
  • Tissue Preservation (methods)
  • Transplantation Conditioning
  • Treatment Outcome

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