Abstract | OBJECTIVE: METHODS: Control male Wistar rats were compared with rats receiving warfarin (20 mg/kg per day) with vitamin K1 (15 mg/kg per day) alone (WVK) or in association with amlodipine (15 mg/kg per day) for 4 weeks or during the last week or last 4 weeks of an 8-week WVK treatment (two regression groups). RESULTS: Inactivation of matrix Gla protein by WVK for 4 or 8 weeks increased the calcium content 10-fold in the aorta, inducing a significant elevation of pulse wave velocity and pulse pressure by selective augmentation of systolic blood pressure. Amlodipine prevented aortic MEC, pulse wave velocity and pulse pressure elevation, but reversed only MEC and pulse pressure when administered for 4 weeks. One week of amlodipine administered after 7 weeks of WVK partially decreased pulse pressure without modifying aortic MEC. Amlodipine did not reduce the fibrosis associated with calcified areas in the WVK model during the regression protocols. CONCLUSION:
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Authors | Rachida Essalihi, Maarten L Zandvliet, Simon Moreau, Liz-Ann Gilbert, Céline Bouvet, Cyrille Lenoël, Fahima Nekka, Marc D McKee, Pierre Moreau |
Journal | Journal of hypertension
(J Hypertens)
Vol. 25
Issue 9
Pg. 1879-86
(Sep 2007)
ISSN: 0263-6352 [Print] England |
PMID | 17762652
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channel Blockers
- Amlodipine
- Collagen
- Calcium
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Topics |
- Amlodipine
(pharmacology, therapeutic use)
- Animals
- Calcinosis
(prevention & control)
- Calcium
(metabolism)
- Calcium Channel Blockers
(pharmacology, therapeutic use)
- Collagen
(metabolism)
- Compliance
(drug effects)
- Hypertension
(drug therapy, physiopathology)
- In Vitro Techniques
- Male
- Rats
- Rats, Wistar
- Systole
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