Treatment of acute soft tissue trauma with a topical non-steroidal anti-inflammatory drug (biphenylacetic acid 3% gel).

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in the treatment of acute soft tissue injuries. However, taken orally, NSAIDs have a definite incidence of gastro-intestinal toxicity. Since acute soft tissue trauma is normally localised, use of a topical NSAID may eliminate this undesirable side-effect. This study was designed to evaluate the efficacy and safety of a topical NSAID, biphenylacetic acid 3% gel (Traxam) in the treatment of soft tissue trauma. Thirty-two patients (22 males and 10 females) with acute soft tissue trauma were enrolled at the Department of Orthopaedic Surgery, National University Hospital, Singapore from 7 June 1988 to 28 March 1989. Each patient was treated for a period of one week with bipenylacetic acid 3% gel (Traxam), 60 mg three times a day. Statistically significant improvement was found in pain, swelling and functional impairment in all patients assessed at day 3 and day 7 after the injury. The speed of recovery was enhanced. The medication was found to be well tolerated and safe.

• Authors: E H Lee, P Y Lee, A T Ngai, E H Chiu
• Journal: Singapore medical journal (Singapore Med J) Vol. 32 Issue 4 Pg. 238-41 (Aug 1991) ISSN: 0037-5675 [Print] India
• PMID: 1776001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Gels
• Phenylacetates
• biphenylylacetic acid

Topics

• Administration, Topical
• Adolescent
• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Contusions (drug therapy)
• Female
• Gels
• Humans
• Male
• Middle Aged
• Phenylacetates (administration & dosage)
• Sprains and Strains (drug therapy)