Genetics of nickel allergic contact dermatitis.

Abstract

Nickel sulfate is the most frequently detected cause of allergic contact dermatitis in the world; the prevalence of nickel allergic contact dermatitis is between 8 and 11% in the general female population. Although it is well recognized that environmental factors are important in the pathogenesis of this dermatitis, some investigators have hypothesized that genetic factors are important as well. This review summarizes animal and human studies evaluating genetic factors in the development of allergic contact dermatitis from nickel.

• Authors: Sarah E Schram, Erin M Warshaw
• Journal: Dermatitis : contact, atopic, occupational, drug (Dermatitis) Vol. 18 Issue 3 Pg. 125-33 (Sep 2007) ISSN: 1710-3568 [Print] United States
• PMID: 17725918 (Publication Type: Journal Article, Review)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 2
• ATP-Binding Cassette Transporters
• Allergens
• HLA Antigens
• Receptors, Antigen, T-Cell
• TAP1 protein, human
• nickel sulfate
• Nickel

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 2
• ATP-Binding Cassette Transporters (genetics)
• Allergens (adverse effects)
• Animals
• Dermatitis, Allergic Contact (etiology, genetics)
• HLA Antigens (genetics)
• Humans
• Models, Animal
• Nickel (adverse effects)
• Receptors, Antigen, T-Cell (genetics)