Effects of gastric electrical stimulation with short pulses and long pulses on gastric dysrhythmia and signs induced by vasopressin in dogs.

Abstract

AIMS:

This study was to investigate the effect of gastric electrical stimulation (GES) with short pulses, long pulses, short-pulse trains or long-pulse trains on gastric dysrhythmia and motion-sickness signs induced by vasopressin.

METHODS:

Seven male beagle dogs implanted with four pairs of electrodes on gastric serosa were studied. The study was performed in six sessions in a randomized order. In session 1 or 2, either saline or vasopressin was infused without GES. In session 3, 4, 5 and 6, GES with short pulses, long pulses, trains of short pulses or trains of long pulses was performed before and during vasopressin infusion. Gastric slow waves and motion-sickness signs were recorded in each session.

RESULTS:

(1) Vasopressin induced gastric dysrhythmia and motion sickness-like signs (ANOVA, P < 0.001). (2) GES with short pulses or trains of short pulses was capable of preventing vasopressin-induced emetic response (P < 0.001), but did not normalize gastric dysrhythmia. (3) GES with long pulses or trains of long pulses was able to normalize gastric dysrhythmia induced by vasopressin (P < 0.001), but showed no effects on vasopressin-induced motion-sickness signs.

CONCLUSION:

GES with short pulses or trains of short pulses prevents vasopressin-induced emetic response with no improvement in gastric dysrhythmia. GES with long pulses or trains of long pulses normalizes gastric dysrhythmia induced by vasopressin with no effects on signs.

• Authors: Xiaohua Hou, Geng-Qing Song, Bin Yang, Yan Sun, Wei Qian, Jiande D Z Chen
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 53 Issue 3 Pg. 630-5 (Mar 2008) ISSN: 0163-2116 [Print] United States
• PMID: 17721728 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Vasopressins

Topics

• Animals
• Dogs
• Electric Stimulation Therapy (methods)
• Gastrointestinal Motility (physiology)
• Male
• Motion Sickness (chemically induced, therapy)
• Stomach Diseases (chemically induced, physiopathology, therapy)
• Vasopressins