Abstract | BACKGROUND: Transdermal (TD) estrogen is often preferred over the oral route in postmenopausal and GH-deficient women taking estrogen, but this has not been studied in detail in girls. OBJECTIVE: DESIGN AND METHODS: Eleven girls with Turner syndrome, mean age 13.4 +/- 0.5 (se) yr, on GH for at least 6 months were recruited. Studies included [(13)C] leucine and d5-glycerol infusions, indirect calorimetry, dual-emission x-ray absorptiometry, and hormone and substrate measurements. They received, in random order, 17beta-estradiol orally (0.5, 1, and 2 mg for 2 wk each) and TD (0.025, 0.0375, and 0.05 mg for 2 wk each), and studies were repeated after each 6-wk course with 4 wk washout in between. RESULTS: Rates of whole-body protein turnover, oxidation and synthesis, lipolysis, lipid and carbohydrate oxidation, and resting energy expenditure were unaffected by either form of estrogen; nor were lipids, insulin, and fibrinogen concentrations affected. Plasma IGF-I concentrations did not change clinically significantly with either form of estrogen, despite higher estrogen concentrations after oral estrogen. Estradiol concentrations did not correlate with any variables measured. CONCLUSIONS: In GH-treated girls with Turner syndrome, neither oral nor TD estrogen adversely affected rates of protein turnover, lipolysis, and lipid oxidation rates or plasma lipids, fibrinogen, or fasting insulin concentrations. There was no clinically significant change in IGF-I concentrations after either form of estrogen. In aggregate, these data suggest that the route of delivery of estrogen does not adversely affect these metabolic effects of GH in young girls with Turner syndrome.
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Authors | Nelly Mauras, Dorothy Shulman, Helen Y Hsiang, Prabhakaran Balagopal, Susan Welch |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 11
Pg. 4154-60
(Nov 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17711924
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Proteins
- Estrogens
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Fibrinogen
- Growth Hormone
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Topics |
- Administration, Cutaneous
- Administration, Oral
- Adolescent
- Body Composition
(drug effects)
- Body Height
(drug effects)
- Body Mass Index
- Calorimetry, Indirect
- Carbohydrate Metabolism
(drug effects)
- Child, Preschool
- Dietary Proteins
(metabolism)
- Estrogens
(administration & dosage, blood, therapeutic use)
- Female
- Fibrinogen
(metabolism)
- Growth Hormone
(therapeutic use)
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor I
(metabolism)
- Kinetics
- Lipid Metabolism
(drug effects)
- Lipid Peroxidation
(drug effects)
- Lipolysis
(drug effects)
- Oxidation-Reduction
- Turner Syndrome
(drug therapy, metabolism, pathology)
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