[Safety and efficacy comparison of myocardial contrast enhancement-guided and angio-pressure-guided transcoronary ablation of septal hypertrophy for patients with hypertrophic obstructive cardiomyopathy].

Abstract

OBJECTIVE:

To compare the safety and efficacy of myocardial contrast enhancement (MCE)-guided and angio-pressure (AP)-guided transcoronary ablation of septal hypertrophy (TASH) for patients with hypertrophic obstructive cardiomyopathy (HOCM).

METHODS:

TASH was performed under MCE-guide (n = 47, group I) or AP-guide (n = 25, group II) for drug-refractory patients with HOCM. Myocardial perfusion imaging (MPI) data as well as other clinical data were compared.

RESULTS:

TASH both under MCE-guide or AP-guide resulted in similar and significant reduction of left ventricular outflow tract gradient (PG) and associated with significant symptom improvement (all P < 0.001). Dosage of ethanol use, peak-level of CK-MB and ablated myocardial area and incidence of arrhythmia were also similar between the two groups.Similar left ventricular/atrial dimension changes post TASH were observed in the 2 groups during follow-up. However, the first selected septal vessels were changed under MCE in 6 patients.

CONCLUSIONS:

Our data demonstrated that the MCE-guided TASH was not superior to AP-guided TASH in safety and efficacy. However, MCE-guided TASH can avoid the misplace of ethanol to avoid innocent myocardial ablation.

• Authors: Yue-chun Gao, Yu Li, Xue-si Wu, Chang-qi Jia, Teng-yong Jiang
• Journal: Zhonghua xin xue guan bing za zhi (Zhonghua Xin Xue Guan Bing Za Zhi) Vol. 35 Issue 6 Pg. 540-3 (Jun 2007) ISSN: 0253-3758 [Print] China
• PMID: 17711715 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)

Topics

• Adult
• Cardiac Catheterization (methods)
• Cardiomyopathy, Hypertrophic (diagnostic imaging, therapy)
• Catheter Ablation (methods)
• Female
• Humans
• Male
• Middle Aged
• Myocardial Perfusion Imaging
• Ultrasonography