[Autoimmune encephalitis with anti-glutamate receptor antibody presenting as epilepsia partialis continua and action myoclonus: a case report].

A 19-year-old man was admitted to our hospital with tremor and myoclonus that appeared after several episodes of consciousness disturbance and generalized convulsions. While steroid therapy resolved these symptoms, epilepsia partialis continua (EPC) and action myoclonus developed. Clobazam improved the EPC, but action myoclonus persisted. Oral tandospirone (30 mg/day) was given because 5-hydroxyindole acetic acid (5-HIAA) was markedly decreased in the cerebrospinal fluid (CSF). After 10 days of this therapy, most action myoclonus disappeared and he could perform fine motor skills. Although the MR structural images were unremarkable, cerebral SPECT showed decreased uptake in the left thalamus and bilateral frontal lobes. The antibody against glutamate receptor subunit epsilon2 was positive in the CSF. This is the first report of autoimmune encephalitis with anti-glutamate receptor antibody presenting as low level of 5-HIAA in the CSF. Tandospirone was effective for action myoclonus.
AuthorsYuji Kato, Yoshihiko Nakazato, Naotoshi Tamura, Ryo Tomioka, Yukitoshi Takahashi, Kunio Shimazu
JournalRinshò„ shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 47 Issue 7 Pg. 429-33 (Jul 2007) ISSN: 0009-918X [Print] Japan
PMID17710887 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Autoantibodies
  • Immunoglobulin G
  • Receptors, Glutamate
  • Adult
  • Autoantibodies (cerebrospinal fluid)
  • Autoimmune Diseases (complications, immunology)
  • Diagnosis, Differential
  • Encephalitis (complications, immunology)
  • Epilepsies, Partial (etiology)
  • Humans
  • Immunoglobulin G (cerebrospinal fluid)
  • Male
  • Myoclonus (etiology)
  • Receptors, Glutamate (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: