Abstract | BACKGROUND/AIMS: METHODOLOGY: Twenty-one patients who had undergone gastrectomy for gastric cancer and had been followed for less than 10 years were assessed for bone disorder by microdensitometry. The levels of 1,25-dihydroxy vitamin D (1,25( OH)2VD), 25-hydroxy vitamin D (25( OH)VD), 24,25-dihydroxy vitamin D (24,25( OH)2VD), N-PTH, calcitonin, estradiol, osteocalcin, and ALP were measured and assessed for correlations with clinicopathological factors, including the operative procedure and the number of years since surgery. RESULTS: Bone disorder was found in 9 out of 21 patients (42.9%). The prevalence was significantly higher in patients who had undergone surgery more than 2 years before assessment, so there was a relationship between the period after surgery and bone disorder. Among the vitamin D metabolites, the level of 1,25( OH)2VD was normal in all patients, whereas 25( OH)VD was reduced in 6 out of 21 patients (28.6%) and 24,25( OH)2VD was reduced in 17 patients (81.0%). The 1,25( OH)2VD was significantly higher in the patients with Grade I to III bone disorder compared to the patients with normal bones or early bone disease. The 1,25( OH)2VD/25( OH)VD ratio was significantly higher in the patients without passage of food through the duodenum due to the reconstructive method, while the 25( OH)VD/24,25( OH)2VD ratio was significantly higher in the patients with remaining of duodenal food passage. PTH was decreased in about 50% of the patients, while calcitonin was normal in all patients. Estradiol was decreased in one female patient, while it was elevated in 10 of the 17 men (58.8%). The osteocalcin level was high in all patients irrespective of the period after surgery. CONCLUSIONS:
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Authors | Yasushi Rino, Yoshinori Takanashi, Yuji Yamamoto, Daisuke Inagaki, Masakazu Kawamoto, Hiroshi Harada, Akio Ashida, Hiroo Wada, Roppei Yamada, Takashi Ohshima, Shinsuke Hatori, Toshio Imada |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2007 Jul-Aug
Vol. 54
Issue 77
Pg. 1596-600
ISSN: 0172-6390 [Print] Greece |
PMID | 17708309
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bone Diseases, Metabolic
(etiology, metabolism)
- Female
- Gastrectomy
(adverse effects)
- Humans
- Male
- Middle Aged
- Stomach Neoplasms
(surgery)
- Vitamin D
(metabolism)
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