Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial.

Abstract

BACKGROUND:

One week of Helicobacter pylori eradication therapy is insufficient for healing of gastric ulcers. We examined the efficacy of rebamipide in gastric ulcer healing following 1 week of eradication therapy in a randomized, double-blind, placebo-controlled trial.

METHODS:

Patients with H. pylori-positive gastric ulcer were enrolled and received 1 week of eradication therapy, followed by 100 mg of rebamipide or placebo for 7 weeks. The primary end point was the gastric ulcer healing rate.

RESULTS:

Of the 309 patients entered in the trial, 301 completed H. pylori eradication therapy; 154 patients took rebamipide, and 147 took placebo. The healing rate in the rebamipide group was higher than that in the placebo group in the per-protocol analysis-80.0% (104/130) versus 66.1% (82/124) [95% confidence interval (CI), 3.1-24.7; P = 0.013)-and in a full analysis-70.1% (108/154) versus 60.5% (89/147) (95% CI, -1.1 to 20.3; P = 0.080).

CONCLUSIONS:

Compared with placebo, rebamipide significantly promoted gastric ulcer healing following 1 week of eradication therapy.

• Authors: Akira Terano, Tetsuo Arakawa, Toshiro Sugiyama, Hidekazu Suzuki, Takashi Joh, Toshikazu Yoshikawa, Kazuhide Higuchi, Ken Haruma, Kazunari Murakami, Kenzo Kobayashi, Rebamipide Clinical Study Group
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 42 Issue 8 Pg. 690-3 (Aug 2007) ISSN: 0944-1174 [Print] Japan
• PMID: 17701133 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Enzyme Inhibitors
• Proton Pump Inhibitors
• Quinolones
• Lansoprazole
• Amoxicillin
• Clarithromycin
• rebamipide
• Alanine

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (therapeutic use)
• Adult
• Alanine (analogs & derivatives, therapeutic use)
• Amoxicillin (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Anti-Ulcer Agents (therapeutic use)
• Clarithromycin (therapeutic use)
• Double-Blind Method
• Endoscopy, Gastrointestinal
• Enzyme Inhibitors (therapeutic use)
• Female
• Follow-Up Studies
• Gastric Mucosa (microbiology, pathology)
• Helicobacter Infections (drug therapy, epidemiology, pathology)
• Helicobacter pylori (isolation & purification)
• Humans
• Japan (epidemiology)
• Lansoprazole
• Male
• Middle Aged
• Prevalence
• Proton Pump Inhibitors
• Quinolones (therapeutic use)
• Retrospective Studies
• Stomach Ulcer (drug therapy, epidemiology, pathology)
• Treatment Outcome