Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction.

Abstract

BACKGROUND:

Pregnancy-associated plasma protein-A (PAPP-A) is a high-molecular-weight, zinc-binding matrix metalloproteinase that is known to be abundantly expressed in ruptured plaques. Previous studies have shown PAPP-A to be a significant marker of plaque instability and cardiovascular events in patients with acute coronary syndromes. Because the activity of PAPP-A may be modulated by genetic variants in the PAPP-A genes, we tried to determine the association of PAPP-A gene with acute myocardial infarction (AMI).

METHODS:

We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively.

RESULTS:

The average age of the study population was 62.2+/-11.4 years in AMI patients and 62.6+/-10.4 years in healthy controls. Multiple logistic regression analysis with risk factors such as age, male sex, smoking, hypertension, diabetes mellitus, and dyslipidemia revealed the PAPP-A IVS6+95 C allele to be associated with an increased risk of AMI (dominancy: odds ratio, 2.13; 95% confidence interval, 1.12-4.07; P=0.022; codominancy: odds ratio, 1.89; 95% confidence interval, 1.14-3.16; P=0.015).

CONCLUSIONS:

We found, for the first time, that PAPP-A IVS6+95 C allele is an independent risk factor for AMI even after adjustment for traditional risk factors. The determination of such genotype contributing to AMI could provide a new tool for identifying high-risk individuals.

• Authors: Sungha Park, Jong-Chan Youn, Dong-Jik Shin, Chan-Mi Park, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Jong-Won Ha, Yangsoo Jang, Namsik Chung
• Journal: Coronary artery disease (Coron Artery Dis) Vol. 18 Issue 6 Pg. 417-22 (Sep 2007) ISSN: 0954-6928 [Print] England
• PMID: 17700210 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pregnancy-Associated Plasma Protein-A

Topics

• Aged
• Alleles
• Case-Control Studies
• Female
• Genotype
• Haplotypes
• Humans
• Logistic Models
• Male
• Middle Aged
• Myocardial Infarction (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Pregnancy-Associated Plasma Protein-A (genetics)
• Risk Factors