Successful treatment of adult T-cell leukemia with unrelated cord blood transplantation.

Abstract

This study reports the first well-documented case of adult T-cell leukemia (ATL) successfully treated with unrelated cord blood transplantation (UCBT). A 49-year-old woman was diagnosed with acute-type of ATL. Chemotherapy induced complete remission, but the human T-cell leukemia virus type 1 (HTLV-1) proviral load was detected in mononuclear cells of her peripheral blood. The patient received UCBT with a conditioning regimen consisting of total body irradiation, cytarabine, and cyclophosphamide. She remains in remission 30 months after UCBT and the HTLV-1 proviral load has fallen to undetectable levels. This result suggests that UCBT should be a therapeutic option for ATL patients who do not have suitable donors and those who urgently require treatment.

• Authors: Jun Takizawa, Sadao Aoki, Tori Kurasaki, Masutaka Higashimura, Keiichiro Honma, Toshiki Kitajima, Akihito Momoi, Hidenobu Takahashi, Naoya Nakamura, Tatsuo Furukawa, Yoshifusa Aizawa
• Journal: American journal of hematology (Am J Hematol) Vol. 82 Issue 12 Pg. 1113-5 (Dec 2007) ISSN: 0361-8609 [Print] United States
• PMID: 17696205 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA Antigens

Topics

• Cord Blood Stem Cell Transplantation (methods)
• Female
• Fetal Blood (immunology, transplantation)
• HLA Antigens (immunology)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (genetics, pathology, therapy)
• Middle Aged
• Skin (pathology)
• Transplantation, Homologous
• Treatment Outcome