Abstract | BACKGROUND: PATIENTS AND METHODS: The functional polymorphisms -13A/G and -33G/A in protein Z and thrombomodulin genes (respectively) influence transcription. The two polymorphisms were investigated in 160 oral cancer patients and 168 controls of equivalent age, gender and ethnicity using restriction fragment length polymorphism typing. RESULTS: The frequency of the -13G allele, which results in lower expression of protein Z gene, was not significantly elevated in patients compared to controls (8.1% and 6.3%, respectively; odds ratio 1.35, 95% confidence interval 0.72-2.56). No carriers of the thrombomodulin low expression -33A allele were identified, underscoring the rarity of this allele in Caucasians. CONCLUSION:
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Authors | Eleftherios Vairaktaris, Zoe Serefoglou, Christos Yapijakis, Emeka Nkenke, Stavros Vassiliou, Sofia Spyridonidou, Antonis Vylliotis, Alexander Michael Nixon, Friedrich Wilhelm Neukam, Efstratios Patsouris |
Journal | Anticancer research
(Anticancer Res)
2007 Jul-Aug
Vol. 27
Issue 4B
Pg. 2449-51
ISSN: 0250-7005 [Print] Greece |
PMID | 17695537
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Proteins
- Thrombomodulin
- plasma protein Z
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Blood Proteins
(biosynthesis, genetics)
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
(blood, genetics)
- Polymorphism, Genetic
- Thrombomodulin
(biosynthesis, genetics)
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