HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment.

Abstract
Aberrant DNA methylation is an important molecular alteration commonly detected in various malignancies. Hypermethylation and expression silencing have been frequently found in multiple genes including those for steroid receptors, tumor suppressors, and DNA repair factors. Differential DNA methylation patterns are detected in type I and type II endometrial cancers, suggesting divergent epigenetic backgrounds and unique tumorigenic pathways. In this review, the implications of new findings in the field of epigenetics are discussed for endometrial cancer prevention, diagnosis, and treatment. DNA methylation-based assays may be explored as a useful adjunct diagnostic tool. Epigenetic modification reagents, including DNA methyltransferase and histone deacetylase inhibitors, when used alone or in combination with conventional chemotherapy, may be beneficial for endometrial cancer patients. Recent studies on epigenetic reactivation of the progesterone receptor provide a novel approach for re-sensitization of advanced, PR-negative endometrial cancers to progestational therapy.
AuthorsX Clare Zhou, Sean C Dowdy, Karl C Podratz, Shi-Wen Jiang
JournalGynecologic oncology (Gynecol Oncol) Vol. 107 Issue 1 Pg. 143-53 (Oct 2007) ISSN: 0090-8258 [Print] United States
PMID17692907 (Publication Type: Journal Article, Review)
Chemical References
  • Histone Deacetylase Inhibitors
  • Receptors, Progesterone
Topics
  • DNA Methylation
  • Endometrial Neoplasms (diagnosis, prevention & control, therapy)
  • Epigenesis, Genetic
  • Female
  • Gene Silencing
  • Histone Deacetylase Inhibitors
  • Humans
  • Receptors, Progesterone

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: