Abstract | PATIENTS AND METHODS: RESULTS: The mean follow-up was 892 +/- 699 days. Twenty-five patients were alive (67.5%) with 3-year patient survivals of 70% for isolated intestinal transplantations and 41% for the multivisceral transplantations (P = .01). The mortality rate was 32.5% with losses due to sepsis (63%) or rejection. Our 3-year graft survival rates were 70% for isolated intestinal transplantations and 41% for multivisceral transplantations (P = .02); graftectomy rate was 16%. These were 88% of grafts working properly with patients on regular diet with no need for parenteral nutrition. DISCUSSION AND CONCLUSIONS: Induction therapy has reduced the doses of postoperative immunosuppressive agents, especially in the first period, lowering the risk of renal failure and sepsis, mucosal surveillance protocol for early detection of rejection dramatically reduced the number of severe acute chronic rejections.
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Authors | A Lauro, C Zanfi, G Ercolani, A Dazzi, L Golfieri, A Amaduzzi, F Pezzoli, G L Grazi, M Vivarelli, M Cescon, G Varotti, M Del Gaudio, M Ravaioli, A Cucchetti, G La Barba, M Zanello, G Vetrone, F Tuci, F Catena, G Ramacciato, L Pironi, A D Pinna |
Journal | Transplantation proceedings
(Transplant Proc)
2007 Jul-Aug
Vol. 39
Issue 6
Pg. 1987-91
ISSN: 0041-1345 [Print] United States |
PMID | 17692673
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Follow-Up Studies
- Graft Survival
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Italy
- Retrospective Studies
- Survival Analysis
- Time Factors
- Tissue and Organ Harvesting
(methods)
- Viscera
(transplantation)
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