Abstract | PURPOSE: Adjuvant, 5-fluorouracil (5-FU)-based chemoradiotherapy for completely resected high-risk gastric adenocarcinoma has been shown to improve survival in a randomized Intergroup trial. However, the results still showed an unsatisfactory outcome. On the basis of previously reported results of a Phase II trial using a more aggressive, cisplatin-containing chemoradiotherapy schedule, we investigated the effects of this approach on long-term renal function. PATIENTS AND METHODS: RESULTS: The prescribed 45 Gy was administered to 100% of the patients, and the cumulative cisplatin dose was 200 mg/m2 in 74% of all patients. In 89%, the constraints concerning the renal absorbed doses were met. The median follow-up for the creatinine and clearance values was 30 and 26 months, respectively. The creatinine values tended to worsen over time without reaching critical levels. We were unable to demonstrate a significant dose-response relationship for renal damage in the tested dose range. CONCLUSIONS: Using a dose constraint of <or=12 Gy for 37.5% of the functional volume of both kidneys appears to be safe at a median follow-up of 2 years for a cumulative cisplatin dose of 200 mg/m2 administered before and after simultaneous 5-FU and radiotherapy.
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Authors | Stefan Welz, Thomas Hehr, Christian Kollmannsberger, Carsten Bokemeyer, Claus Belka, Wilfried Budach |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 69
Issue 5
Pg. 1429-35
(Dec 01 2007)
ISSN: 0360-3016 [Print] United States |
PMID | 17692474
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study)
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Chemical References |
- Biomarkers
- Creatinine
- Paclitaxel
- Cisplatin
- Leucovorin
- Fluorouracil
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Topics |
- Adult
- Aged
- Analysis of Variance
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Biomarkers
(blood)
- Chemotherapy, Adjuvant
(adverse effects)
- Cisplatin
(administration & dosage, adverse effects)
- Creatinine
(blood)
- Esophagogastric Junction
- Female
- Fluorouracil
(administration & dosage, adverse effects)
- Humans
- Kidney
(drug effects, radiation effects)
- Leucovorin
(administration & dosage)
- Male
- Middle Aged
- Paclitaxel
(administration & dosage, adverse effects)
- Radiotherapy Dosage
- Radiotherapy, Adjuvant
(adverse effects)
- Stomach Neoplasms
(drug therapy, radiotherapy)
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