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[Successful treatment of angiosarcoma with liposomal-encapsulated doxorubicin].

Abstract
Cutaneous angiosarcoma is a rare tumor of endothelial origin, often difficult to diagnose and with an unfavorable prognosis. A 85-year-old woman presented with an extensive angiosarcoma involving her right leg. The tumor was not clinically typical but the diagnosis was confirmed histologically. Because of her age and the extent of the tumor, we elected to treat primarily with cobalt-60 irradiation. The tumor unfortunately progressed during radiation therapy, so we decided to begin palliative chemotherapy with liposome-encapsulated doxorubicin. The patient received six cycles of doxorubicin (Caelyx, 15 mg/m(2) i.v. in four-week intervals) which was well-tolerated and led to complete regression of angiosarcoma which has lasted for 6 months. Chemotherapy with liposome-encapsulated doxorubicin may represent a well-tolerable therapeutic option in cases where surgery and irradiation are not possible or fail. Further studies are necessary to prove the efficacy of doxorubicin therapy in angiosarcoma.
AuthorsA Voss, C S Seitz, C Rose, E B Bröcker, M Goebeler
JournalDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 52 Issue 10 Pg. 895-8 (Oct 2001) ISSN: 1432-1173 [Electronic] Germany
Vernacular TitleErfolgreiche Therapie eines Angiosarkoms mit liposomal verkapseltem Doxorubizin.
PMID17690822 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Liposomes
  • Doxorubicin
Topics
  • Aged, 80 and over
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Doxorubicin (administration & dosage, chemistry)
  • Drug Carriers (administration & dosage, chemistry)
  • Female
  • Hemangiosarcoma (drug therapy, pathology)
  • Humans
  • Leg (pathology)
  • Liposomes (chemistry)
  • Skin Neoplasms (drug therapy)
  • Treatment Outcome

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