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Experience with intravenous metronidazole to treat moderate-to-severe amebiasis in Japan.

Abstract
Twenty-eight cases of either intestinal amebiasis, amebic liver abscess, or both, most of which were of moderate-to-severe intensity, were treated with intravenous metronidazole, pioneered by the Research Group on Chemotherapy of Tropical Diseases, Japan. This study was not conducted as a formal clinical trial, and all patients either underwent colectomy for intestinal amebiasis, received oral metronidazole, or both. Despite these limitations, intravenous metronidazole was shown to be well tolerated and seemed to be very effective. This agent should be more widely recommended than previously thought for treating moderate-to-severe amebiasis, especially its intestinal form.
AuthorsMikio Kimura, Tetsuya Nakamura, Yukifumi Nawa
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 77 Issue 2 Pg. 381-5 (Aug 2007) ISSN: 0002-9637 [Print] United States
PMID17690418 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiprotozoal Agents
  • Metronidazole
Topics
  • Adult
  • Aged
  • Amebiasis (drug therapy)
  • Antiprotozoal Agents (adverse effects, therapeutic use)
  • Female
  • Humans
  • Injections, Intravenous
  • Japan
  • Male
  • Metronidazole (adverse effects, therapeutic use)
  • Middle Aged

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