Abstract | AIM:
Combined vaccines have an increasingly important role to play in delivering these antigens acceptably. We describe the immunogenicity and reactogenicity of a combined DTPa-HBV-IPV vaccine ( diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus ( DTPa-HBV-IPV: Infanrix penta) ) when administered for the primary vaccination of infants resulting from a study where the primary objective was to demonstrate non-inferiority of the immune response induced by DTPa-HBV-IPV using an industrial-scale IPV production process. METHODS: Three hundred and fourteen infants received primary immunisation with DTPa-HBV-IPV at 2, 4 and 6 months of age. Routine Haemophilus influenzae immunisation was performed at 2 and 4 months of age at a separate injection site. Blood samples were taken at 2 and 7 months of age. Reactogenicity was assessed using diary cards for 7 days after each dose. RESULTS: CONCLUSIONS: The DTPa-HBV-IPV vaccine is a new combination of vaccines previously available separately, with established effectiveness and safety profiles. Combined vaccines reduce storage requirements and minimise the number of injections required, thereby reducing distress for infants and parents. DTPa-HBV-IPV was immunogenic with an acceptable safety profile and could replace separate administration of DTPa, HBV and IPV vaccines in infants.
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Authors | Terry Nolan, Stephen Lambert, Don Roberton, Helen Marshall, Peter Richmond, Catherine Streeton |
Journal | Journal of paediatrics and child health
(J Paediatr Child Health)
Vol. 43
Issue 9
Pg. 587-92
(Sep 2007)
ISSN: 1034-4810 [Print] Australia |
PMID | 17688642
(Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Antibodies, Viral
- Diphtheria-Tetanus-acellular Pertussis Vaccines
- Hepatitis B Vaccines
- Poliovirus Vaccine, Inactivated
- Vaccines, Combined
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Topics |
- Antibodies, Bacterial
(blood)
- Antibodies, Viral
(blood)
- Diphtheria-Tetanus-acellular Pertussis Vaccines
(administration & dosage, immunology)
- Hepatitis B Vaccines
(administration & dosage, immunology)
- Humans
- Immunization Schedule
- Infant
- Poliovirus Vaccine, Inactivated
(administration & dosage, immunology)
- Vaccines, Combined
(administration & dosage, immunology)
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