Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis.

Abstract	A variety of factors affect the development of endometriosis, including hormonal status and genetic factors. The growth of endometriosis is stimulated by local estrogen production in conjunction with circulating estrogen. The CYP19 gene encodes a steroid aromatase that catalyses the conversion of C-19 androgens to estrogens. This study investigated whether polymorphisms of the CYP19 gene are associated with the risk of advanced endometriosis in Korean women. Blood samples were collected from 224 female patients with endometriosis of stages III and IV, as diagnosed by both pathologic and laparoscopic findings, and from a control group comprising of 188 women undergoing laparoscopic surgery or laparotomy for nonmalignant lesions. Single-nucleotide polymorphisms, restriction fragment length polymorphisms, and tetranucleotide tandem repeat polymorphisms were discriminated by the polymerase chain reaction (PCR). Haplotype analysis was also performed. CYP19 115T>C, 240G>A, and 1531C>T polymorphisms and [TTTA]n tetranucleotide repeat polymorphisms in the CYP19 gene and their haplotypes were not significantly associated with the risk of endometriosis. The risk of endometriosis also did not increase significantly with the number of higher risk alleles of the CYP19 gene. In conclusion, our findings suggest that CYP19 genetic polymorphisms are not associated with advanced-stage endometriosis in Korean women.
Authors	Sung Eun Hur, Sara Lee, Ji Young Lee, Hye-Sung Moon, Hyung Lae Kim, Hye Won Chung
Journal	Journal of human genetics (J Hum Genet) Vol. 52 Issue 9 Pg. 703-711 ( 2007) ISSN: 1434-5161 [Print] England
PMID	17687621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Estrogens Aromatase
Topics	Aromatase (genetics, metabolism) Case-Control Studies Endometriosis (genetics, metabolism) Estrogens (genetics, metabolism) Female Genetic Predisposition to Disease Genotype Haplotypes Humans Korea Linkage Disequilibrium Polymorphism, Genetic

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