Abstract |
Even though benefits of vaccination policies have been widely demonstrated, vaccine injections might be associated with rare side effects. In this setting, the potential role of vaccines, mostly against hepatitis B virus, in the induction of autoimmunity has been a matter of controversy. We report the case of a woman followed for a lupus panniculitis which had been in remission for 3 years, who developed a lupus flare following an anti- hepatitis-B vaccine injection. The topography of recurring lupus lesions, the chronology of the flare and the increase in the antinuclear autoantibody serum level all supported a causal role for vaccination in the relapse of the lupus lesions. We believe that the present case might provide a first observation of lupus panniculitis possibly induced by hepatitis B vaccination, and this should be added to the range of dysimmune manifestations caused by vaccinations.
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Authors | A Choffray, L Pinquier, H Bachelez |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 215
Issue 2
Pg. 152-4
( 2007)
ISSN: 1421-9832 [Electronic] Switzerland |
PMID | 17684379
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright (c) 2007 S. Karger AG, Basel. |
Chemical References |
- Antibodies, Antinuclear
- Hepatitis B Vaccines
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Topics |
- Aged
- Antibodies, Antinuclear
(blood)
- Female
- Hepatitis B Vaccines
(adverse effects)
- Humans
- Panniculitis, Lupus Erythematosus
(chemically induced, pathology)
- Recurrence
- Skin
(pathology)
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