[The study on the relationship between Rsa I, Alu I polymorphism of the estrogen receptor beta gene and unknown aetiology hypomenorrhea].

Abstract

OBJECTIVE:

To study the relationship between estrogen receptor beta gene (ER beta) polymorphism and unknown aetiology hypomenorrhea in Southwestern China .

METHODS:

One hundred eumenorrhea women were chosen as control group and another 100 hypomenorrhea patients as case group from Southwestern China. Restriction fragment length polymorphism (RFLP) of the Rsa I and Alu I in ER beta gene was analysed. The ER beta gene polymorphism genotype distribution in case group and control group was compared.

RESULTS:

R allele frequency in case and control groups was 37.5% and 48.5% respectively, the OR was 0.64 (95%CI: 0.42-0.97), P= 0.026. A allele frequency in case and control groups was 18.0% and 11.5% respectively, the OR was 1.69 (95%CI: 0.93-3.09), P= 0.07. RFLP of Rsa I and Alu I in both groups were distributed with polymorphism.

CONCLUSION:

ERbeta gene polymorphism has a relation with unknown aetiological hypomenorrhea. R allele may be the guard factor, and A allele may be its risk factor.

• Authors: Rui Yuan, Ai-wen Le, Li Gen, En-lan Xia, Zhen-wei Yao
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 24 Issue 4 Pg. 425-7 (Aug 2007) ISSN: 1003-9406 [Print] China
• PMID: 17680534 (Publication Type: English Abstract, Journal Article)

Chemical References

• Estrogen Receptor beta
• endodeoxyribonuclease AluI
• Deoxyribonucleases, Type II Site-Specific
• GTAC-specific type II deoxyribonucleases

Topics

• Adult
• Binding Sites (genetics)
• Deoxyribonucleases, Type II Site-Specific (metabolism)
• Estrogen Receptor beta (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Menstruation Disturbances (etiology, genetics)
• Polymerase Chain Reaction
• Polymorphism, Genetic (genetics)
• Polymorphism, Restriction Fragment Length
• Young Adult