Abstract | BACKGROUND & AIMS: Enteric glia participates to the homeostasis of the gastrointestinal tract. In the central nervous system, increased expression of astroglial-derived S100B protein has been associated with the onset and maintaining of inflammation. The role of enteric glial-derived S100B protein in gastrointestinal inflammation has never been investigated in humans. In this study, we evaluated the expression of S100B and its relationship with nitric oxide production in celiac disease. METHODS: RESULTS: CONCLUSIONS: Enteric glial-derived S100B is increased in the duodenum of patients with celiac disease and plays a role in nitric oxide production.
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Authors | Giuseppe Esposito, Carla Cirillo, Giovanni Sarnelli, Daniele De Filippis, Francesco Paolo D'Armiento, Alba Rocco, Gerardo Nardone, Raffaella Petruzzelli, Michela Grosso, Paola Izzo, Teresa Iuvone, Rosario Cuomo |
Journal | Gastroenterology
(Gastroenterology)
Vol. 133
Issue 3
Pg. 918-25
(Sep 2007)
ISSN: 0016-5085 [Print] United States |
PMID | 17678654
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nerve Growth Factors
- Nitrites
- RNA, Messenger
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
- S100B protein, human
- Nitric Oxide
- Gliadin
- Nitric Oxide Synthase Type II
- p38 Mitogen-Activated Protein Kinases
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Topics |
- Adult
- Aged
- Astrocytes
(metabolism)
- Biopsy
- Case-Control Studies
- Celiac Disease
(metabolism, pathology)
- Duodenum
(innervation, metabolism, pathology)
- Gliadin
(pharmacology)
- Humans
- Intestinal Mucosa
(drug effects, metabolism, pathology)
- Middle Aged
- Nerve Growth Factors
(genetics, metabolism)
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase Type II
(genetics, metabolism)
- Nitrites
(metabolism)
- Organ Culture Techniques
- RNA, Messenger
(genetics, metabolism)
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
(genetics, metabolism)
- p38 Mitogen-Activated Protein Kinases
(genetics, metabolism)
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