[Laminin and heparan sulfate proteoglycan of the basal membrane in basal cell cancer (an immunohistochemical study using monoclonal antibodies)].

Abstract

Levels of laminin and heparan sulfate proteoglycan (basal membrane components) were studied immunohistochemically in samples prepared from 18 basal-cell carcinomas using indirect immunoperoxidase technique. In the majority of cases, the basal membrane surrounding tumor foci remained unaltered. Some areas of solid basaliomas revealed defects in the membrane as well as deposits of laminin (but not heparan sulfate proteoglycan) in tumor tissue. It was suggested that areas of basalioma are surrounded by chemically defective membrane.

• Authors: S V Petrov, A N Raĭkhlin
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 37 Issue 5 Pg. 550-3 ( 1991) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Laminin i geparansul'fat proteoglikan bazal'noĭ membrany kozhy pri basal'no-kletochnom rake (immunogistokhimicheskoe issledovanie s pomoshch'iu monoklonal'nykh antitel).
• PMID: 1767508 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Heparan Sulfate Proteoglycans
• Laminin
• Proteoglycans
• Heparitin Sulfate

Topics

• Aged
• Antibodies, Monoclonal
• Carcinoma, Basal Cell (chemistry)
• Female
• Heparan Sulfate Proteoglycans
• Heparitin Sulfate (analysis)
• Humans
• Immunoenzyme Techniques
• Laminin (analysis)
• Male
• Middle Aged
• Proteoglycans (analysis)
• Skin (chemistry)
• Skin Neoplasms (chemistry)