Phenoxymethylpenicillin two or three times daily for tonsillitis with beta-haemolytic streptococci group A: a blinded, randomized and controlled clinical study.

Abstract

In relation to compliance problems it was investigated whether phenoxymethylpenicillin dosed twice or 3 times daily was equally effective in tonsillitis due to beta-haemolytic streptococci group A. In a randomized, controlled and single blind multicentre study 206 patients older than 5 years with a positive culture of group A streptococci were treated with phenoxymethylpenicillin for 7 days. 101 patients received the daily dosage divided in 2 doses and 105 patients divided in 3 doses a day. The cure rate (a combination of bacteriological and clinical cure) was 82.0% in the 2-dosage regimen, and 88.2% in the 3-dosage regimen. The difference was not statistically significant. In conclusion, phenoxymethylpenicillin dosed 2 or 3 times daily seems to be equally effective in tonsillitis due to group A streptococci.

• Authors: G Fyllingen, A R Arnesen, C Biermann, O Kaarby, O Romfo, J Rønnevig, J Aaserud
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 23 Issue 5 Pg. 553-8 ( 1991) ISSN: 0036-5548 [Print] England
• PMID: 1767251 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Penicillin V

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Drug Administration Schedule
• Female
• Humans
• Male
• Norway
• Penicillin V (administration & dosage, therapeutic use)
• Single-Blind Method
• Streptococcal Infections (drug therapy, microbiology)
• Streptococcus pyogenes
• Tonsillitis (diagnosis, drug therapy, microbiology)