HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Compacting DNA during the interphase: condensin maintains rDNA integrity.

Abstract
During mitosis, condensin is responsible for folding chromatin fibers into highly compact chromosomes, ensuring the faithful segregation of replicated chromosomes into daughter cells after each cell division. Our laboratory has unexpectedly found that condensin is capable of condensing DNA during the interphase: upon nutrient starvation, condensin is loaded to the rDNA array, leading to DNA condensation in this region. This subchromosomal DNA condensation appears to protect the integrity of the rDNA array. These observations provide the first microscopic evidence of DNA compaction by condensin outside mitosis. In addition, they show that condensin is also highly regulated outside mitosis.
AuthorsChi Kwan Tsang, Yuehua Wei, X F Steven Zheng
JournalCell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 6 Issue 18 Pg. 2213-8 (Sep 15 2007) ISSN: 1551-4005 [Electronic] United States
PMID17671437 (Publication Type: Journal Article, Review)
Chemical References
  • DNA, Ribosomal
  • DNA-Binding Proteins
  • Multiprotein Complexes
  • condensin complexes
  • DNA
  • Adenosine Triphosphatases
Topics
  • Adenosine Triphosphatases (chemistry, physiology)
  • Animals
  • DNA (chemistry, metabolism)
  • DNA, Ribosomal (chemistry, metabolism)
  • DNA-Binding Proteins (chemistry, physiology)
  • Humans
  • Interphase (genetics)
  • Mitosis (genetics)
  • Multiprotein Complexes (chemistry, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: