An open multicenter phase II trial of docetaxel-gemcitabine in Charlson score and performance status (PS) selected elderly patients with stage IIIB pleura/IV non-small-cell lung cancer (NSCLC): the GFPC 02-02a study.

Abstract

UNLABELLED:

The aim of this study was to determine the impact of patient selection based on age, comorbidity and performance status on the efficacy of platinum-free combination therapy on non-small-cell lung cancer after 65 years of age. We analyzed the overall response rate, the median survival time, the 1-year survival rate, toxicity and quality of life after one to three 6-week cycles of docetaxel 30mg/m(2) weekly and gemcitabine 900mg/m(2) at weeks 1, 2, 4 and 5. Fifty patients (median age 73.7 years) were eligible. The mean number of comorbid conditions per patient was 0.8 [Balducci L. Lung cancer and aging. ASCO 2005. Educational book. p. 587-91; Piquet J, Blanchon F, Grivaux M, et al. Primary bronchial carcinoma in elderly subjects in France. Rev Mal Respir 2003;20:691-9; Jatoi A, Hillman S, Stella P, et al. Should elderly non-small-cell lung cancer patients be offered elderly-specific trials? Results of a pooled analysis from the North Central Cancer Treatment Group. J Clin Oncol 2005;23:9113-9; Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist 2000;5:224-37]. Forty-five patients were assessable: 17 (34%) had an objective response, 18 (36%) had stable disease and 10 progressed (20%). The median survival time was 7 months and the 1-year survival rate 23.5%. The main grade III-IV adverse event was neutropenia (32% of patients).

CONCLUSION:

Platinum-free dual-agent chemotherapy gives similar results in patients over 65, selected on the basis of their precise age and comorbidity, to that reported in younger subjects.

• Authors: H LeCaer, P Fournel, H Jullian, C Chouaid, J Letreut, P Thomas, D Paillotin, M Perol, C Gimenez, A Vergnenegre
• Journal: Critical reviews in oncology/hematology (Crit Rev Oncol Hematol) Vol. 64 Issue 1 Pg. 73-81 (Oct 2007) ISSN: 1040-8428 [Print] Netherlands
• PMID: 17669664 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Antimetabolites, Antineoplastic
• Taxoids
• Deoxycytidine
• Docetaxel
• Gemcitabine

Topics

• Age Factors
• Antimetabolites, Antineoplastic
• Antineoplastic Combined Chemotherapy Protocols
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Comorbidity
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Docetaxel
• Humans
• Neoplasm Staging
• Patient Selection
• Pleural Neoplasms (drug therapy, pathology)
• Severity of Illness Index
• Taxoids (administration & dosage)
• Treatment Outcome
• Gemcitabine