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[Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms].

AbstractINTRODUCTION:
Human Papilloma Virus has a strong relation to oropharyngeal mucosa and is considered to be responsible for a wide range of upper respiratory tract pathologies, like laryngeal papilloma. There's a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm's. MATERIAL AND METHODIC. The examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6--middle ear malignant neoplasm, and 1 middle and/or external ear benign neoplasm. The control group consisted of 5 patients operated on: otosclerosis--4 cases and post-traumatic tympanic membrane perforation--1 case. The material was postoperative tissue, like polyps, inflammatory granulation tissue, cholesteatoma masses and malignant neoplasm's tissue.
RESULTS:
In the whole group of 53 examined cases, HPV DNA was confirmed in 22 cases (41.5%), in that group oncogenic types 16 or 18 in 12 cases (22.6%), and in 14 cases (26.4%) types 6 or 11. In a group of chronic granulomatous otitis media DNA characteristic for Papilloma was identified in 12 cases (25.6%), in it in 9 cases DNA HPV type 6 or 11 was confirmed, and in 7 cases type 16 or 18. Among cholesteatomatous chronic otitis media HPV DNA types 6 or 11 was identified in 70%. In every case of middle ear malignant neoplasm a presence of high-risk DNA Papilloma types 16 or 18 was confirmed. In any case of control group HPV DNA was detected.
CONCLUSIONS:
The results has been compared with other authors examinations and it is claimed that they confirm the observation, that Human Papilloma Viruses may be a factor, that might play an important role in pathology of chronic otitis media and ear neoplasm's. It is concluded, that differences in percentages of HPV presence in chronic inflammations (70%) and ear neoplasm's may be explained by viral co-infection during bacterial c. o. m. Viral infection probably evolves carcinogenesis, which leads to a neoplastic growth.
AuthorsBogdan Rydzewski, Anna Goździcka-Józefiak, Jerzy Sokalski, Monika Matusiak, Lukasz Durzyński
JournalOtolaryngologia polska = The Polish otolaryngology (Otolaryngol Pol) Vol. 61 Issue 2 Pg. 137-41 ( 2007) ISSN: 0030-6657 [Print] Poland
Vernacular TitleIdentyfikacja wirusów ludzkich brodawczaków (HPV) w stanach zapalnych i nowotworach uszu.
PMID17668798 (Publication Type: English Abstract, Journal Article)
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Cholesteatoma, Middle Ear (epidemiology, virology)
  • Ear (virology)
  • Ear Neoplasms (epidemiology, virology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Otitis Media (epidemiology, virology)
  • Papilloma (epidemiology, genetics, virology)
  • Papillomavirus Infections (classification, diagnosis, epidemiology, virology)
  • Poland (epidemiology)
  • Polymerase Chain Reaction
  • Prognosis
  • Tumor Virus Infections (diagnosis, epidemiology, virology)

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