Abstract | PURPOSE: Few complications have been reported for deep lamellar endothelial keratoplasty (DLEK). Endothelial graft failure has rarely been disclosed as a complication. Although the histopathologic and ultrastructural analysis of a failed DLEK graft has been previously described, we are not aware of any reports of these features in a case of traumatic endothelial graft failure. METHODS: RESULTS: Marked endothelial loss resulting in corneal decompensation was diagnosed histopathologically. The graft-host interface line showed no substantial findings for the following histochemical and immunohistochemical stains: colloidal iron, alcian blue (pH 2.5), vimentin, epithelial membrane antigen (EMA), smooth muscle actin (SMA), anti- cytokeratin CAM 5.2, high-molecular-weight keratin, anti- cytokeratin AE1/AE3, and collagen 3. The cornea showed ultrastructural changes similar to, but more pronounced than, those observed in corneas after laser in situ keratomileusis. CONCLUSIONS: This is the second described case of endothelial graft failure after DLEK. Histochemical and ultrastructural analysis revealed that the DLEK-operated cornea contained irregularities that may interfere with optical performance.
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Authors | Patrick Gooi, Jennifer W Robinson, Seymour Brownstein, Guillermo Rocha |
Journal | Cornea
(Cornea)
Vol. 26
Issue 7
Pg. 853-7
(Aug 2007)
ISSN: 0277-3740 [Print] United States |
PMID | 17667621
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aged, 80 and over
- Biomarkers
(metabolism)
- Cell Count
- Corneal Edema
(etiology, surgery)
- Corneal Transplantation
(adverse effects)
- Endothelium, Corneal
(metabolism, transplantation, ultrastructure)
- Eye Proteins
(metabolism)
- Fuchs' Endothelial Dystrophy
(surgery)
- Graft Rejection
(etiology, metabolism, pathology, surgery)
- Humans
- Keratoplasty, Penetrating
- Male
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