Ethanolamine oleate sclerotherapy versus simple cyst aspiration in the management of orbitopalpebral cyst associated with congenital microphthalmos.

Abstract

PURPOSE:

To evaluate the efficacy of ethanolamine oleate (EO) sclerotherapy in the management of orbitopalpebral cysts associated with congenital microphthalmos, and compare it with simple cyst aspiration.

METHODS:

Retrospective, interventional comparative case series of 12 orbitopalpebral cysts of 8 patients associated with congenital microphthalmos. Five cysts were treated with simple aspiration and 7 cysts with EO sclerotherapy. Cyst resolution was the main outcome measure.

RESULTS:

Five cysts underwent aspiration alone at a median age of 12 weeks. One (20%; 95% CI, 0%-55.1%) of these 5 showed complete resolution. Seven cysts (6 patients) underwent aspiration combined with EO sclerotherapy at a median age of 30 weeks (3 had recurred following prior cyst aspiration). Postsclerotherapy, 6 eyes (85.7%; 95% CI, 59.8%-100%) showed complete cyst resolution (p = 0.072, Fisher exact test). The mean follow-up was 8.8 months (range, 3-23 months). In the EO group, 1 cyst (14.3%) required repeat sclerotherapy and another cyst showed partial resolution at 6 weeks. The number needed to treat with sclerotherapy to prevent 1 recurrence was 2 (1-5, 95% CI). No procedure-related complications were noted.

CONCLUSIONS:

Simple aspiration of orbitopalpebral cyst is associated with a high recurrence rate and should be reserved for early prognostication of visual potential in the microphthalmic eye. Minimally invasive EO sclerotherapy provides a rapid, effective, and uncomplicated treatment modality for definitive therapy, and should be preferred in cases with no visual prognosis in the microphthalmic eye demonstrating adequate bony orbital expansion.

• Authors: Milind N Naik, Santosh G Honavar, Ramesh K Murthy, Kuldeep Raizada, Ravi Thomas
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2007 Jul-Aug Vol. 23 Issue 4 Pg. 307-11 ISSN: 0740-9303 [Print] United States
• PMID: 17667104 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Oleic Acids
• Sclerosing Solutions
• ethanolamine oleate

Topics

• Child, Preschool
• Cysts (complications, therapy)
• Eyelid Diseases (complications, therapy)
• Follow-Up Studies
• Humans
• Infant
• Infant, Newborn
• Microphthalmos (complications)
• Oleic Acids (therapeutic use)
• Orbital Diseases (complications, therapy)
• Recurrence
• Sclerosing Solutions (therapeutic use)
• Sclerotherapy (methods)
• Suction (methods)
• Treatment Outcome