Correlation between P53 expression and CD34 angiogenic factor in Tunisian breast cancer.

Abstract

BACKGROUND:

Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defined.

AIM:

The purpose of this study was to investigate P53 expression in breast cancer and to examine the relationship between P53 overexpression and the degree of angiogenesis.

METHODS:

A total of 52 paraffin-embedded tumors were evaluated immunohistochemically for expression of P53 and CD34 angiogenesis factor.

RESULTS:

The majority of P53 positive cases (82%) demonstrated high level of microvessel density (MVD); 18% demonstrated no CD 34 expression. In contrast there was no variation of CD34 expression among P53 negative tumors.

CONCLUSION:

This data suggests that microvessel density is promoted by P53 overexpression in breast cancer, and is correlated with high histologic grade.

• Authors: Asma Fourati, Fathi Khomsi, Michele V El May, Khaled Rahal, Amor Gamoudi, Hamouda Boussen, Mansour Ben Abdallah, Ahmed El May
• Journal: La Tunisie medicale (Tunis Med) Vol. 85 Issue 2 Pg. 105-8 (Feb 2007) ISSN: 0041-4131 [Print] Tunisia
• PMID: 17665654 (Publication Type: Journal Article)

Chemical References

• Antigens, CD34
• Tumor Suppressor Protein p53

Topics

• Adult
• Aged
• Antigens, CD34 (metabolism)
• Breast Neoplasms (blood supply, metabolism, pathology)
• Female
• Humans
• Middle Aged
• Neovascularization, Pathologic
• Prospective Studies
• Tumor Suppressor Protein p53 (metabolism)