Abstract |
The etiology of lichen planus (LP) is still unknown and previous studies have found an association between LP and HLA-DR1, DR2, DR3, DR9 and DR10 in different populations. The aim of this study was to analyze the distribution of the HLA-DRB1 alleles in Mexican Mestizo patients with LP. The aim of this study was to determine the gene frequency of HLA-DR locus in Mexican Mestizo patients with LP. We studied 20 patients with LP and 99 healthy Mexican Mestizo controls. HLA-DRB1 was performed by PCR-SSO reverse dot blot hybridization. High resolution HLA typing was performed by PCR-SSP. The HLA-DRB1*0101 allele was associated significantly in LP patients compared with healthy controls (pC = 0.0007, OR = 5.46, 95% CI = 1.86-16.06). HLA-DRB1*0101 is a marker for the development of LP in Mexican Mestizo population, yet another gene or HLA marker within MHC region may be the causatively associated gene.
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Authors | P Luis-Montoya, J K Yamamoto-Furusho, E Vega-Memije, A Rodríguez-Carreón, J A Ruiz-Morales, G Vargas-Alarcón, L Domínguez-Soto, J Granados |
Journal | Archives of dermatological research
(Arch Dermatol Res)
Vol. 299
Issue 8
Pg. 405-7
(Oct 2007)
ISSN: 0340-3696 [Print] Germany |
PMID | 17665209
(Publication Type: Journal Article)
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Chemical References |
- Genetic Markers
- HLA-A Antigens
- HLA-DRB1 Chains
- HLA-DRB1*01:01 antigen
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Topics |
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
(ethnology)
- HLA-A Antigens
(genetics)
- HLA-DRB1 Chains
- Histocompatibility Testing
- Humans
- Lichen Planus
(ethnology, genetics)
- Mexico
(epidemiology)
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