Abstract | BACKGROUND: Treatment of focal hyperhidrosis with botulinum toxin A (BTX-A) is known to be effective in the axillary, palmar, and plantar region. No studies evaluating the treatment of hyperhidrosis in the anal fold with BTX-A are available, however. OBJECTIVE: The objective was to evaluate whether or not injections with BTX-A are an effective therapy option for the treatment of focal hyperhidrosis of the anal fold. MATERIAL AND METHODS: Eleven male patients (median age, 28.3 years) with focal hyperhidrosis of the anal fold as assessed by modified iodine- starch test were enrolled. Each patient received intradermal injections with 38 U on average (30-54 U) of BTX-A ( BOTOX, Allergan Inc.). Changes in sweat rates were documented by comparing the size of hyperhidrotic area in square centimeters before and 4 weeks after injection. RESULTS: The mean reduction of hyperhidrotic area was 29.9 cm(2) (range, 27-43 cm(2)), corresponding to a reduction of 78.5%. Apart from painful injections, no side effects were observed. CONCLUSION:
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Authors | Falk G Bechara, Michael Sand, Reinhard K Achenbach, Daniel Sand, Peter Altmeyer, Klaus Hoffmann |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 33
Issue 8
Pg. 924-7
(Aug 2007)
ISSN: 1076-0512 [Print] United States |
PMID | 17661934
(Publication Type: Journal Article)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Adult
- Anus Diseases
(drug therapy)
- Botulinum Toxins, Type A
(therapeutic use)
- Humans
- Hyperhidrosis
(drug therapy)
- Male
- Neuromuscular Agents
(therapeutic use)
- Remission Induction
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