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Focal hyperhidrosis of the anal fold: successful treatment with botulinum toxin A.

AbstractBACKGROUND:
Treatment of focal hyperhidrosis with botulinum toxin A (BTX-A) is known to be effective in the axillary, palmar, and plantar region. No studies evaluating the treatment of hyperhidrosis in the anal fold with BTX-A are available, however.
OBJECTIVE:
The objective was to evaluate whether or not injections with BTX-A are an effective therapy option for the treatment of focal hyperhidrosis of the anal fold.
MATERIAL AND METHODS:
Eleven male patients (median age, 28.3 years) with focal hyperhidrosis of the anal fold as assessed by modified iodine-starch test were enrolled. Each patient received intradermal injections with 38 U on average (30-54 U) of BTX-A (BOTOX, Allergan Inc.). Changes in sweat rates were documented by comparing the size of hyperhidrotic area in square centimeters before and 4 weeks after injection.
RESULTS:
The mean reduction of hyperhidrotic area was 29.9 cm(2) (range, 27-43 cm(2)), corresponding to a reduction of 78.5%. Apart from painful injections, no side effects were observed.
CONCLUSION:
BTX-A is an effective therapy for patients with focal hyperhidrosis of the anal fold.
AuthorsFalk G Bechara, Michael Sand, Reinhard K Achenbach, Daniel Sand, Peter Altmeyer, Klaus Hoffmann
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 33 Issue 8 Pg. 924-7 (Aug 2007) ISSN: 1076-0512 [Print] United States
PMID17661934 (Publication Type: Journal Article)
Chemical References
  • Neuromuscular Agents
  • Botulinum Toxins, Type A
Topics
  • Adult
  • Anus Diseases (drug therapy)
  • Botulinum Toxins, Type A (therapeutic use)
  • Humans
  • Hyperhidrosis (drug therapy)
  • Male
  • Neuromuscular Agents (therapeutic use)
  • Remission Induction

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