[Metaiodobenzylguanidine scintigraphy in the diagnosis and followup of neuroblastoma. Apropos of 16 cases].

Abstract

AIMS:

The aim of this study is to evaluate meta-iodo-benzyl-guanidine scintigraphy in the diagnosis and the management of neuroblastoma.

PATIENTS AND METHODS:

betwen september 1999 and jun 2004, 16 children aging from 4 months to 6 years, with neuroblastoma, underwent mIBG scintigraphy in military hospital nuclear medicine department.

RESULTS:

23 mIBG scans were done. The exam was indicated for the initial staging in 7 cases, to evaluate chemotherapy or surgery in 12 cases and to seek for reccurences in 3 cases. The sensitivity of mIBG was 57% in the detection of the primary tumor, 100% for liver metastases and 67% for medullar involvement.

CONCLUSION:

mIBG scintigraphy should be a standard in the initial staging of neuroblastoma and in evaluating therapy response.

• Authors: Hatem Hammami, Latifa Hassine, Aida Mhiri, Ali Sellem, Fayçal Oubich, Lamia Gharssallah, Sihem Barsaoui, Habib Ben Brahim
• Journal: La Tunisie medicale (Tunis Med) Vol. 85 Issue 5 Pg. 413-6 (May 2007) ISSN: 0041-4131 [Print] Tunisia
• Vernacular Title: La scintigraphie à la méta-iodo-benzyl-guanidine dans le diagnostic et le suivi des neuroblastomes. A propos de 16 cas.
• PMID: 17657930 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Radiopharmaceuticals
• 3-Iodobenzylguanidine

Topics

• 3-Iodobenzylguanidine
• Abdominal Neoplasms (diagnostic imaging, drug therapy, surgery)
• Antineoplastic Agents (therapeutic use)
• Bone Marrow Neoplasms (diagnostic imaging, secondary)
• Child
• Child, Preschool
• Female
• Follow-Up Studies
• Humans
• Infant
• Liver Neoplasms (diagnostic imaging, secondary)
• Male
• Neoplasm Recurrence, Local (diagnostic imaging)
• Neoplasm Staging
• Neuroblastoma (diagnostic imaging, drug therapy, surgery)
• Radionuclide Imaging
• Radiopharmaceuticals
• Retrospective Studies
• Sensitivity and Specificity