Abstract | BACKGROUND: Drugs that target microtubules, including paclitaxel ( Taxol) and docetaxel ( Taxotere), are among the most commonly prescribed anticancer therapies. However, the utility of taxane-based therapies is limited by difficulties with formulation, administration, and resistance induced by P-glycoprotein. The epothilones are a novel class of antimicrotubule agents that have demonstrated antitumor activity in the setting of resistance. DESIGN: This review summarizes clinical studies of epothilones in patients with metastatic breast cancer. Data were identified by searches of PubMed and the Proceedings of the American Society of Clinical Oncology annual meetings from 2000 to 2006. RESULTS: CONCLUSIONS:
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Authors | M N Fornier |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 18 Suppl 5
Pg. v16-21
(Jul 2007)
ISSN: 0923-7534 [Print] England |
PMID | 17656557
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Epothilones
- Tubulin Modulators
- ixabepilone
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Topics |
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Breast Neoplasms
(drug therapy)
- Drug Therapy, Combination
- Epothilones
(pharmacology, therapeutic use)
- Female
- Humans
- Neoadjuvant Therapy
- Treatment Outcome
- Tubulin Modulators
(pharmacology, therapeutic use)
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