Impact of delta-sarcoglycan gene polymorphism on the occurrence of coronary spastic angina in Japanese patients with hypertrophic cardiomyopathy.

Abstract

BACKGROUND:

Patients with hypertrophic cardiomyopathy (HCM) frequently complain of angina-like symptoms in the absence of organic coronary stenoses. Coronary spasm might cause myocardial ischemia in HCM patients. Delta-sarcoglycan plays a crucial role in the pathogenesis of HCM and coronary spasm in a mouse model.

METHODS AND RESULTS:

This is a retrospective, single-center study with a small sample size. Seventy patients with HCM underwent coronary angiography and received acetylcholine provocation test. Coronary risk factors and 5'-untranslated region (UTR) G to C polymorphism on delta-sarcoglycan gene (n=64) were evaluated in the HCM patients. In 31 (44.3%) of 70 HCM patients, coronary spasm was induced by the provocation. None of the coronary risk factors was significantly different between the coronary spasm group and the non-coronary spasm group. The 5'-UTR gene polymorphism was associated with the occurrence of coronary spasm with an additive effect on the coexistence (p=0.025). Multiple logistic regression analysis showed that the C allele of 5'-UTR polymorphism was a significant risk factor for coronary spasm in patients with HCM (odds ratio, 3.1; 95% confidence interval, 1.0 to 9.5; p=0.045) that was independent of traditional coronary risk factors.

CONCLUSIONS:

The 5'-UTR polymorphism on delta-sarcoglycan gene was associated with coronary spasm in Japanese patients with HCM.

• Authors: Tsuyoshi Honda, Seigo Sugiyama, Tomohiro Sakamoto, Koichi Kaikita, Hisao Ogawa
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 71 Issue 8 Pg. 1263-7 (Aug 2007) ISSN: 1346-9843 [Print] Japan
• PMID: 17652892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5' Untranslated Regions
• Sarcoglycans

Topics

• 5' Untranslated Regions
• Aged
• Angina Pectoris
• Cardiomyopathy, Hypertrophic (complications)
• Coronary Vasospasm (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Japan
• Male
• Middle Aged
• Polymorphism, Genetic
• Retrospective Studies
• Sarcoglycans (genetics)