Abstract | BACKGROUND: OBJECTIVES: METHODS: A total of 64 subjects were considered, including 10 HbSS genotypic subjects with P. falciparum parasitemia (HbSS+PfM), 18 HbAA genotypic subjects with P. falciparum parasitemia (HbAA+PfM), 20 HbSS without P. falciparum parasitemia (HbSS-PfM), and 16 HbAA genotypic subjects without P. falciparum parasitemia ( HbAA-PfM). IgM, IgA, IgG, C1 inhibitor, and C3 activator titers were quantified by single radial immunodiffusion method. RESULTS: The mean levels of IgG in HbSS+PfM (2373.90+/-1772.81mg/dl) and HbAA+PfM (1868.80+/-0.00mg/dl) were significantly higher compared with HbSS-PfM (644.55+/-171.15mg/dl) or HbAA-PfM (659.75+/-158.01mg/dl) patients. HbAA-PfM subjects had the lowest level of IgM (67.27+/-63.7mg/dl), though no significant difference was observed comparing mean levels of IgM between the four groups. IgA titer was significantly higher in HbSS-PfM patients (249.00+/-94.8mg/dl) compared with HbAA-PfM (p<0.05), HbAA+PfM (p<0.05), or HbSS+PfM (p<0.05). The mean values of C1 inhibitor were lower in HbSS+PfM and HbAA+PfM compared with HbSS-PfM or HbAA-PfM. However, HbAA+PfM had a significantly lower value of C1 inhibitor compared with HbAA-PfM (p<0.01). C3 activator was highest in HbSS-PfM (17.10+/-7.35mg/dl) and was significantly higher compared with HbSS+PfM (p<0.05). CONCLUSION: Increased C1 inhibitor and decreased C3 activator in HbSS+PfM compared with HbAA+PfM shows that deranged regulation of complement factors may be responsible for increased susceptibility of HbSS to P. falciparum malaria.
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Authors | Ganiyu Arinola, Chris Ezeh |
Journal | Iranian journal of immunology : IJI
(Iran J Immunol)
Vol. 4
Issue 1
Pg. 44-9
(Mar 2007)
ISSN: 1735-1383 [Print] Iran |
PMID | 17652843
(Publication Type: Journal Article)
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Chemical References |
- Complement C1 Inactivator Proteins
- Complement C1 Inhibitor Protein
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- SERPING1 protein, human
- Serpins
- Complement C3-C5 Convertases
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Topics |
- Animals
- Complement C1 Inactivator Proteins
- Complement C1 Inhibitor Protein
- Complement C3-C5 Convertases
(analysis)
- Hemoglobin SC Disease
(blood, immunology)
- Humans
- Immunoglobulin A
(blood)
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Malaria, Falciparum
(blood, immunology, parasitology)
- Nigeria
- Plasmodium falciparum
(isolation & purification)
- Serpins
(blood)
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