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Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases.

AbstractAIMS:
To elucidate the role of fascin in oral and oropharyngeal squamous cell carcinoma (OSCC) by correlation with clinical parameters.
METHODS AND RESULTS:
Paraffin sections using tissue microarrays of 129 patients with OSCC were investigated immunohistochemically. Fascin protein was overexpressed in OSCC cells compared with their non-neoplastic epithelial counterparts. For evaluating the intensity of fascin, 39 (30.2%) were classified as weakly immunoreactive, 76 (58.9%) as moderate reactive and 14 (10.9%) as intensely reactive. For evaluating the distribution of fascin, 64 (49.6%) were classified as < 55% and 65 (50.4%) were classified as >/= 55%. Fascin protein expression was correlated with size or extent of the tumour (P < 0.001), positive lymph node metastasis (P < 0.001), distant metastasis (P = 0.014) and clinical staging (P < 0.001). The immunoreactivity scores of fascin in OSCC were variable but showed significant correlation with histological grade, clinical TNM system and stage.
CONCLUSION:
Expression of fascin protein may play an important role in progression of OSCC. Overexpression of fascin contributes to a more aggressive clinical course and suggests the potential of fascin as a new molecular target for therapeutic intervention.
AuthorsS F Chen, S F Yang, J W Li, P C Nieh, S Y Lin, E Fu, C Y Bai, J S Jin, C Y Lin, S Nieh
JournalHistopathology (Histopathology) Vol. 51 Issue 2 Pg. 173-83 (Aug 2007) ISSN: 0309-0167 [Print] England
PMID17650213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carrier Proteins
  • Microfilament Proteins
  • fascin
Topics
  • Adult
  • Aged
  • Carcinoma, Squamous Cell (metabolism, pathology, secondary)
  • Carrier Proteins (metabolism)
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis
  • Male
  • Microfilament Proteins (metabolism)
  • Middle Aged
  • Mouth Neoplasms (metabolism, pathology)
  • Neoplasm Staging
  • Oropharyngeal Neoplasms (metabolism, pathology)
  • Prognosis
  • Protein Array Analysis

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