Abstract | AIMS: METHODS AND RESULTS:
Paraffin sections using tissue microarrays of 129 patients with OSCC were investigated immunohistochemically. Fascin protein was overexpressed in OSCC cells compared with their non-neoplastic epithelial counterparts. For evaluating the intensity of fascin, 39 (30.2%) were classified as weakly immunoreactive, 76 (58.9%) as moderate reactive and 14 (10.9%) as intensely reactive. For evaluating the distribution of fascin, 64 (49.6%) were classified as < 55% and 65 (50.4%) were classified as >/= 55%. Fascin protein expression was correlated with size or extent of the tumour (P < 0.001), positive lymph node metastasis (P < 0.001), distant metastasis (P = 0.014) and clinical staging (P < 0.001). The immunoreactivity scores of fascin in OSCC were variable but showed significant correlation with histological grade, clinical TNM system and stage. CONCLUSION: Expression of fascin protein may play an important role in progression of OSCC. Overexpression of fascin contributes to a more aggressive clinical course and suggests the potential of fascin as a new molecular target for therapeutic intervention.
|
Authors | S F Chen, S F Yang, J W Li, P C Nieh, S Y Lin, E Fu, C Y Bai, J S Jin, C Y Lin, S Nieh |
Journal | Histopathology
(Histopathology)
Vol. 51
Issue 2
Pg. 173-83
(Aug 2007)
ISSN: 0309-0167 [Print] England |
PMID | 17650213
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carrier Proteins
- Microfilament Proteins
- fascin
|
Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(metabolism, pathology, secondary)
- Carrier Proteins
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Male
- Microfilament Proteins
(metabolism)
- Middle Aged
- Mouth Neoplasms
(metabolism, pathology)
- Neoplasm Staging
- Oropharyngeal Neoplasms
(metabolism, pathology)
- Prognosis
- Protein Array Analysis
|