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Expression of HPV, steroid receptors (ERalpha, ERbeta, PR-A and PR-B) and inhibin/activin subunits (alpha, betaA and betaB) in adenosquamous endometrial carcinoma.

AbstractAIM:
The aim of the study was to determine possible pathogenetic factors and molecules which may be used as tumor markers of adenosquamous endometrial carcinoma.
MATERIALS AND METHODS:
Eight adenosquamous endometrial carcinomas were immunohistochemically tested with specific monoclonal antibodies for HPV (polyclonal anti-HPV and monoclonal anti-HPV 18), estrogen receptors ER-alpha and ER-beta, progesterone receptors PR-A and PR-B and the inhibin/activin subunits inhibin-alpha, -betaA and -betaB.
RESULTS:
HPV 18 and the polyclonal HPV antibody was detected in all adenosquamous endometrial carcinomas, both in the endometrioid (n = 7/8) and squamous (n = 8/8) parts of the tumor. Neither ER-alpha or ER-beta were detectable in any tumor, in contrast to PR-A and PR-B which were detected in about half of these tumors (PR-A: n = 5/8 and PR-B: n = 2/8). Inhibin-alpha and -betaB were not detected, while inhibin-betaA was expressed in all adenosquamous carcinomas.
CONCLUSION:
The carcinogenesis of adenosquamous endometrial carcinomas was associated with HPV infection. Adenosquamous endometrial carcinomas seem not to be controlled by estrogens. The absence of the expression of the inhibin-alpha subunit suggests a tumor-suppressive function in adenosquamous endometrial tumors. The absence of the expression of the inhibin-betaB subunit, which is probably a marker of differentiation, points to the malignancy of these tumors. The other inhibin subunit, inhibin-betaA, was expressed in all adenosquamous tumors. It remains to be clarified if these parameters can be used as tumor markers.
AuthorsAndrea Gingelmaier, Stefanie Gutsche, Ioannis Mylonas, Naim Shabani, Christina Kuhn, Susanne Kunze, Udo Jeschke, Klaus Friese
JournalAnticancer research (Anticancer Res) 2007 Jul-Aug Vol. 27 Issue 4A Pg. 2011-7 ISSN: 0250-7005 [Print] Greece
PMID17649814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Viral
  • Biomarkers, Tumor
  • Receptors, Steroid
  • Activins
  • Inhibins
Topics
  • Activins (biosynthesis)
  • Adult
  • Aged
  • Antigens, Viral (biosynthesis)
  • Biomarkers, Tumor (analysis)
  • Carcinoma, Adenosquamous (metabolism, virology)
  • Endometrial Neoplasms (metabolism, virology)
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibins (biosynthesis)
  • Middle Aged
  • Papillomaviridae
  • Papillomavirus Infections (epidemiology)
  • Receptors, Steroid

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