[Anti-neutrophil cytoplasmic anti body (ANCA)-negative limited form of Wegener's granulomatosis; report of a case].

Abstract

A 54-year-old man, who was suspected to suffer from multi-drug resistant lung abcess, was admitted to our hospital. Chest computed tomography (CT) scan showed large cavitary mass in right S6 and nodules in left S1+2 and S10. No abnormal findings were detected without raised immunoglobulin E (IgE) and C-reactive protein (CRP). Anti-neutrophil cytoplasmic antibody (ANCA) was repeatedly negative. We couldn't make a diagnosis by percutaneous biopsy. Finally we performed open lung biopsy of left lung, and Wegener's granulomatosis was diagnosed at last He improved immediately after treatment with prednisolone, cyclophosphamide and sulfamethoxazole-trimethoprim. ANCA-negative Wegener's granulomatosis should be considered when we diagnose multiple pulmonary nodules.

• Authors: Nobuyuki Sato, H Tsubochi, K Kishimoto, T Imai, M Kaimori
• Journal: Kyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 60 Issue 7 Pg. 591-4 (Jul 2007) ISSN: 0021-5252 [Print] Japan
• PMID: 17642224 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Biomarkers
• Trimethoprim, Sulfamethoxazole Drug Combination
• Cyclophosphamide
• Prednisolone

Topics

• Antibodies, Antineutrophil Cytoplasmic
• Biomarkers
• Biopsy
• Cyclophosphamide (therapeutic use)
• Diagnosis, Differential
• Drug Therapy, Combination
• Granulomatosis with Polyangiitis (diagnosis, drug therapy, pathology)
• Humans
• Lung (pathology)
• Male
• Middle Aged
• Prednisolone (therapeutic use)
• Treatment Outcome
• Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)