Abstract |
The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase.
|
Authors | A K Jäger, I M S Eldeen, J van Staden |
Journal | Phytotherapy research : PTR
(Phytother Res)
Vol. 21
Issue 12
Pg. 1251-2
(Dec 2007)
ISSN: 0951-418X [Print] England |
PMID | 17639563
(Publication Type: Journal Article)
|
Copyright | Copyright (c) 2007 John Wiley & Sons, Ltd. |
Chemical References |
- Cyclooxygenase 2 Inhibitors
- Plant Extracts
|
Topics |
- Cyclooxygenase 2 Inhibitors
(analysis)
- Fruit
(chemistry)
- Osteoarthritis
(drug therapy)
- Phytotherapy
- Plant Extracts
(chemistry, therapeutic use)
- Rosa
(chemistry)
|