Effect of oral CDP-choline on visual function in young amblyopic patients.

Abstract

PURPOSE:

The purpose of the study was to evaluate the effect on visual function of orally administered CDP-choline in addition to patching for the treatment of amblyopia in children.

METHODS:

This was an open label parallel group study comparing patching plus oral CDP-choline with patching alone. Sixty-one participants (aged between 5 and 10 years) suffering from anisometropic or strabismic amblyopia were divided at random into two groups: Group A, 800 or 1,200 mg (according to the body weight) of orally administered CDP-choline and 2-h patching a day; Group B, 2-h patching a day. Both groups were treated for 30 consecutive days. A follow-up visit was set 60 days after the treatment was discontinued. The main outcome measure was the change in visual acuity of amblyopic eyes as measured by Snellen's E charts. The secondary outcome measures were changes in the visual acuity of amblyopic eye as measured by isolated letters (Snellen's E) and changes in the contrast sensitivity of amblyopic eyes.

RESULTS:

The addition of CDP-choline to patching therapy was not found to be more effective than patching alone after 30-day treatment. The present results showed that adding CDP-choline to patching stabilised the effects obtained during the treatment period. In fact, whereas the participants treated only with patching showed a decrease in visual acuity at 90 days, these receiving CDP-choline and patching combined appeared to maintain the results obtained (two-way ANOVA: P = 0.0042). Similar results were obtained when measuring visual acuity by isolated Snellen's E letters.

CONCLUSIONS:

In amblyopic patients, CDP-choline combined with patching contributes to obtaining more stable effects than patching alone.

• Authors: Michela Fresina, Anna Dickmann, Annabella Salerni, Fabio De Gregorio, Emilio C Campos
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 246 Issue 1 Pg. 143-50 (Jan 2008) ISSN: 1435-702X [Electronic] Germany
• PMID: 17638004 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cytidine Diphosphate Choline

Topics

• Administration, Oral
• Amblyopia (physiopathology, therapy)
• Child
• Child, Preschool
• Combined Modality Therapy
• Cytidine Diphosphate Choline (administration & dosage)
• Female
• Humans
• Male
• Sensory Deprivation
• Visual Acuity (physiology)