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Aloe-emodin-induced apoptosis in human gastric carcinoma cells.

Abstract
The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. We demonstrate that aloe-emodin induced cell death in a dose- and time-dependent manner. Noteworthy is that the AGS cells were generally more sensitive than the NCI-N87 cells. Aloe-emodin caused the release of apoptosis-inducing factor and cytochrome c from mitochondria, followed by the activation of caspase-3, leading to nuclear shrinkage and apoptosis. In addition, exposure to aloe-emodin suppressed the casein kinase II activity in a time-dependent manner and was accompanied by a reduced phosphorylation of Bid, a downstream substrate of casein kinase II and a pro-apoptotic molecule. These preclinical studies suggest that aloe-emodin represents a suitable and novel chemotherapeutic drug candidate for the treatment of human gastric carcinoma.
AuthorsSheng-Hsuan Chen, Kai-Yuan Lin, Chun-Chao Chang, Chia-Lang Fang, Chih-Ping Lin
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 45 Issue 11 Pg. 2296-303 (Nov 2007) ISSN: 0278-6915 [Print] England
PMID17637488 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthraquinones
  • Antineoplastic Agents, Phytogenic
  • Apoptosis Inducing Factor
  • BH3 Interacting Domain Death Agonist Protein
  • BID protein, human
  • Cytochromes c
  • aloe emodin
  • Casein Kinase II
Topics
  • Anthraquinones (pharmacology)
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Apoptosis (drug effects)
  • Apoptosis Inducing Factor
  • BH3 Interacting Domain Death Agonist Protein (metabolism)
  • Carcinoma (drug therapy)
  • Casein Kinase II (metabolism)
  • Cell Line, Tumor
  • Cytochromes c
  • Dose-Response Relationship, Drug
  • Humans
  • Phosphorylation
  • Stomach Neoplasms (drug therapy)
  • Time Factors

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