[Single-lung transplantation for end-stage pulmonary parenchymal diseases with pulmonary hypertension].

To observe the outcome of single-lung transplantation (SLT) for end-stage pulmonary parenchymal diseases in combination with pulmonary hypertension (PH).
From September 2002 to November 2005, there were 22 lung transplantation recipients, suffering from emphysema (10/22), pulmonary fibrosis (10/22), pneumosilicosis (1/22) and vascular leiomyoma (1/22), and all of them were complicated with pulmonary hypertension to different extent. Operative techniques: 10 patients received left-lung transplantations, and 12 patients received right-lung transplantation. In all the patients echocardiography (ECHO) was performed before transplantation, and arterial blood was collected to determine oxygenation index (PaO(2)/FiO(2)).
The systolic pulmonary artery pressure (Ppa, syst) was monitored by Swan-Gans catheterization one week post-transplantation, and it was found to have decreased significantly [from (50.00+/-13.00) mm Hg (1 mm Hg=0.133 kPa) to (39.5+/-7.36) mm Hg,P<0.05]. Simultaneously, PaO(2)/FiO(2) was improved [from (241.26+/-79.54) mm Hg to (348.23+/-99.31) mm Hg, P<0.05].
Single lung transplantation is an efficient way to deal with end-stage pulmonary parenchymal disease combined with pulmonary hypertension.
AuthorsYan-hong Zhu, Jing-yu Chen, Ming-feng Zheng, Sheng Chang, Yi-jun He, Yong-gong Wang
JournalZhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) Vol. 19 Issue 7 Pg. 401-3 (Jul 2007) ISSN: 1003-0603 [Print] China
PMID17631705 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
  • Adult
  • Aged
  • Blood Pressure (physiology)
  • Female
  • Humans
  • Hypertension, Pulmonary (etiology, physiopathology)
  • Lung Diseases (complications, surgery)
  • Lung Transplantation (methods)
  • Male
  • Middle Aged
  • Pulmonary Artery (physiopathology)
  • Pulmonary Emphysema (complications, surgery)
  • Pulmonary Fibrosis (complications, surgery)
  • Treatment Outcome

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