DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A.

Abstract

DNA ploidy distribution, measured in experimental renal tumours that occurred in twelve ageing male Fischer rats derived from carcinogenicity experiments on ochratoxin A (OTA) in response to chronic dietary exposure, was diploid in all renal adenomas and aneuploid in all carcinomas, correlating with their typical organised and disorganised histopathology, respectively. Aneuploidy was also detected in renal tissue in which karyomegaly, induced by OTA, was analogous to that caused by the fungus Penicillium polonicum. Thus, the experimental rat renal carcinoma could arise within an adenoma directly from certain persistent karyomegalic tubular epithelial cells long after their particular genetic damage has been caused during a protracted period of OTA insult.

• Authors: Amy L Brown, Edward W Odell, Peter G Mantle
• Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (Exp Toxicol Pathol) Vol. 59 Issue 2 Pg. 85-95 (Oct 2007) ISSN: 0940-2993 [Print] Germany
• PMID: 17629687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• DNA, Neoplasm
• Ochratoxins
• ochratoxin A

Topics

• Adenoma (chemically induced, genetics, pathology)
• Aneuploidy
• Animals
• Carcinogens (toxicity)
• Carcinoma (chemically induced, genetics, secondary)
• Cell Nucleus (pathology)
• DNA, Neoplasm (genetics)
• Diet
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Kidney Neoplasms (chemically induced, genetics, pathology)
• Male
• Ochratoxins (toxicity)
• Rats
• Rats, Inbred F344