Plasma cytokine levels in ulcerative colitis.

Abstract

BACKGROUND/AIMS:

Some immunological factors are responsible in the pathogenesis of ulcerative colitis. There is a relationship between cytokines and ulcerative colitis.

METHODOLOGY:

In this study 20 ulcerative colitis patients (mean age 36.2 years old, 9 women, 11 men) and 20 healthy control groups (mean age 27.2 years old, 11 women, 9 men) were involved in the study.

RESULTS:

We established that IL-2Rsp, IL-6, IL-8 and IL-10 levels were different at the patients and control groups (p < 0.005). TNF-alpha and IL-1 beta were similar at the both groups.

CONCLUSIONS:

According to these results, IL-2Rsp, IL-6, 11-8 and IL-10 play an important role in the pathogenesis of ulcerative colitis. We consider that these cytokines are beneficial parameters in the diagnosis, treatment and prognosis of ulcerative colitis.

• Authors: Vedat Goral, Tahir Celenk, Abdurahman Kaplan, Dede Sit
• Journal: Hepato-gastroenterology (Hepatogastroenterology) Vol. 54 Issue 76 Pg. 1130-3 (Jun 2007) ISSN: 0172-6390 [Print] Greece
• PMID: 17629054 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Cytokines

Topics

• Adult
• Biomarkers, Tumor (blood)
• Colitis, Ulcerative (diagnosis)
• Cytokines (blood)
• Female
• Humans
• Male
• Prognosis