Abstract | PURPOSE: METHODS: Long-term survivors of OS and ES currently undergoing routine follow-up care were reviewed and noted for the development of a new secondary malignancy. Details of their initial evaluation, previous therapies, resection techniques, pathologic findings, and follow-up compose this report. RESULTS: Two patients, a 17-year-old adolescent boy with OS and 16-year-old adolescent girl with ES, with secondary mucoepidermoid carcinoma of the parotid gland were identified. Both patients underwent primary resection and chemotherapy including alkylating agents, but neither received radiation. The mucoepidermoid carcinomas developed 27 months and 132 months after completion of therapy, respectively, and were noted on routine yearly follow-up. Fine-needle aspiration was nondiagnostic on each, and parotidectomy with preservation of the facial nerve was performed. Pathology revealed low-grade mucoepidermoid carcinoma with tumor extending to the deep margins for both lesions, and radiotherapy to the parotid bed was administered. There were no surgical complications. One patient is alive, without evidence of recurrent mucoepidermoid carcinoma after 4 years; the other recently completed radiotherapy and is disease-free after 12 months. CONCLUSION:
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Authors | Daniel N Rutigliano, Paul Meyers, Ronald A Ghossein, Diane L Carlson, Mark L Kayton, Dennis Kraus, Michael P La Quaglia |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 42
Issue 7
Pg. E9-13
(Jul 2007)
ISSN: 1531-5037 [Electronic] United States |
PMID | 17618873
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adolescent
- Bone Neoplasms
(drug therapy, pathology, surgery)
- Carcinoma, Mucoepidermoid
(pathology, radiotherapy, surgery)
- Combined Modality Therapy
- Female
- Humans
- Male
- Neoplasms, Second Primary
(pathology, radiotherapy, surgery)
- Osteosarcoma
(drug therapy, pathology, surgery)
- Parotid Neoplasms
(pathology, radiotherapy, surgery)
- Sarcoma, Ewing
(drug therapy, pathology, surgery)
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