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[Correlation of free L-carnitine level with accessory gland markers and its clinical significance].

AbstractOBJECTIVE:
To evaluate the correlation of the level of free L-carnitine with accessory gland markers and its clinical significance.
METHODS:
Semen samples from 30 fertile men and 222 infertile patients were collected by masturbation. The measurement of the semen quality was carried out by computer-assisted semen analysis system. The seminal plasma components of free L-carnitine, alpha-glucosidase, fructose and acid phosphatase were determined. The results obtained were statistically calculated with an SPSS 12.0 program to evaluate the difference between the control group and the infertile one and the correlation of the free L-carnitine levels with the seminal plasma components of alpha-glucosidase, fructose and acid phosphatase.
RESULTS:
The concentration of free L-carnitine (P < 0.01) and the activity of alpha-glucosidase (P < 0.05) were significantly reduced in the infertile group as compared with the control, with no significant difference in the concentration of fructose and the activity of acid phosphatase between the two groups. There was a statistically significant positive correlation between seminal plasma free L-carnitine level and alpha-glucosidase activity (r = 0.504, P < 0.001.
CONCLUSION:
The determination of free L-carnitine level in seminal plasma is a useful test in the evaluation of epididymal function, which may serve as a guidance for the clinical treatment of male infertility as well as for the study on the mechanisms of male reproduction.
AuthorsKe Li, Wei Li, Yu-feng Huang, Xue-jun Shang
JournalZhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 13 Issue 6 Pg. 507-10 (Jun 2007) ISSN: 1009-3591 [Print] China
PMID17615973 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fructose
  • Acid Phosphatase
  • alpha-Glucosidases
  • Carnitine
Topics
  • Acid Phosphatase (analysis, metabolism)
  • Adult
  • Carnitine (analysis, metabolism)
  • Case-Control Studies
  • Fructose (analysis)
  • Humans
  • Infertility, Male (metabolism, physiopathology)
  • Male
  • Semen (chemistry)
  • alpha-Glucosidases (analysis)

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